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KMID : 0370219770210040184
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Yakhak Hoeji
1977 Volume.21 No. 4 p.184 ~ p.192
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Coordination Chemical Approach to the Safety of Nitrofuran Drugs I. Reduction of Nitrofurazone Catalyzed by Molybdothiol Complexes
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김종윤/Kim JY
최보길/Choi BG
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Abstract
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In the presence of dithionite, two kinds of molybdothiol complexes, particularly isolated Mo-cysteine complexes, used as models for xanthine oxidase or aldehyde oxidase exhibited catalytic activity on the reduction of nitrofurazone to its amino derivative. Of the two Mo-cysteine complexes, the activity of oxo-bridged one was apparently greater than that of sulfido-bridged one. The promoting effect was hardly shown by added cofactors or their replacements of the enzymes. The catalyzed reduction is considered to take place by consecutive direct two-electron transfer mechanism from catalytically active reduced form of the molybdothiol complexes to nitrofurazone and the probable intermediates.
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